Search for: All records

Chemistry in water, leveraging its solvent properties, provides a safer and more sustainable alternative to traditional organic solvent methods. 

Initial calculations of environmental footprints associated with using NivsPd catalysis in a representative metal-catalyzed Suzuki–Miyaura cross-coupling reveal that the choice of ligated metal is often NOT of consequence. Rather, it is a culmination of other parameters such as medium. 

Abstract Toxic organic solvents and electrolytes, traditionally indispensable for electro‐organic synthesis, are now being reconsidered. In developing more sustainable electro‐organic synthesis, we've harnessed the aqueous micelles as solvents and electrolyte‐like structures when deformed under an electric field. The technology is showcased in synthetically highly valued hydrodefluorination reactions of difluorinated indoles. This mild electrosynthetic method produces monofluorinated unprotected indole scaffolds. Our approach minimizes waste and enhances atom economy, reducing reliance on expensive and hazardous solvents and electrolytes. The surfactant's potential for recycling was verified for two cycles. Cyclic voltammetry analysis has corroborated that PS‐750‐M micelles in water establish a more efficient platform for hydrodefluorination. Our technology simplifies the production of monofluorinated indoles, which are crucial for many drug‐like molecules.